Triamcinolone Acetonide for the Treatment of Diabetic Macular Oedema
نویسنده
چکیده
Diabetic macular oedema is a major cause of severe visual loss whose pathogenesis appears to be complex and multifactorial. For many years laser photocoagulation has been the standard of care for the treatment of this condition. Emerging pharmacologic approaches are being evaluated through randomised controlled trials. Triamcinolone acetonide has been proposed as a promising option, due to its well-known anti-inflammatory, anti-permeability and anti-angiogenic properties. Intravitreal delivery allows bypassing of the blood–retinal barrier to achieve a more concentrated dose of steroid in the vitreal cavity for a prolonged time. Intravitreal triamcinolone acetonide is effective in reducing central macular thickness and improving visual acuity, even if the duration of action is often provisional and requires repeated injections. Drug-related and injection-related side effects have been reported; the most common are induced cataract and increased intraocular pressure. To extend the duration of steroid effects and to minimise the risk of complications, alternative routes of administration and extend-release implants are being investigated.
منابع مشابه
Dosage dependency of intravitreal triamcinolone acetonide as treatment for diabetic macular oedema.
AIM To evaluate the effect of different doses of intravitreal triamcinolone acetonide on diffuse diabetic macular oedema. METHODS The prospective, randomised, double masked, clinical interventional study included 27 eyes (27 patients) with diffuse diabetic macular oedema. They were randomly divided into three study groups receiving an intravitreal injection of filtered triamcinolone acetonide...
متن کاملIntravitreal triamcinolone versus laser photocoagulation as a primary treatment for diabetic macular oedema - a comparative pilot study
BACKGROUND Diabetic macular oedema is the leading causes of blindness. Laser photocoagulation reduces the risk of visual loss. However recurrences are common and despite laser treatment, patients with diabetic macular oedema experienced progressive loss of vision. Stabilization of the blood retinal barrier introduces a rationale for intravitreal triamcinolone treatment in diabetic macular oedem...
متن کاملEffect of Intravitreal Triamcinolone Acetonide on Improvement of Visual Acuity and Resolution of Diffuse Diabetic Macular Oedema
Subclinical inflammation occurring in diabetic retinopathy is supposed to be, at least partly, the cause of breakage of blood-retinal barrier. It may be expected that anti-inflammatory drugs have favorable effect on the course of diabetic macular oedema. The aim was to investigate the effect of intravitreally applied triamcinolone acetonide (TA) on resolution of diffuse diabetic macular oedema ...
متن کاملDiffuse diabetic macular oedema treated by intravitreal triamcinolone acetonide: a comparative, non-randomised study.
AIM To report on visual outcome of patients receiving an intravitreal injection of triamcinolone acetonide for treatment of diffuse diabetic macular oedema. METHODS Prospective, comparative, non-randomised clinical interventional study included 136 patients with diffuse diabetic macular oedema. Patients of the study group (97 eyes) received an intravitreal injection of 20-25 mg of triamcinolo...
متن کاملIntravitreal versus sub-Tenon triamcinolone acetonide for refractory diffuse diabetic macular oedema
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Intravitreal triamcinolone acetonide for the treatment of diffuse diabetic macular oedema--a case report.
INTRODUCTION Although laser photocoagulation is the primary treatment for diabetic macular oedema, treatment of eyes with diffuse macular oedema has been disappointing. Intravitreal injection of steroids is being investigated for the treatment of diabetic macular oedema. Preliminary results indicate that steroid injections do improve macular oedema, but it is not clear if they improve visual ac...
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